Searchable abstracts of presentations at key conferences in endocrinology

ea0063p1001 | Environment, Society and Governance | ECE2019

Halogenous derivatives of Bisphenol A inhibit the human FSH receptor activity

Sibilia Paul , Doumas Manon , Gourdin Louis , Briet Claire , Carato Pascal , Rodien Patrice , Munier Mathilde

Numerous epidemiological studies link exposure to Bisphenol A (BPA) to reproductive function anomalies. Our team recently showed that BPA inhibits the action of Follicle Stimulating Hormone (FSH) on its receptor (FSHR). Water decontamination is achieved by chloration, which leads to the formation of chlorinated derivatives of Bisphenol A (ClXBPA), that may be found in natural environments and biological liquids or organs. In the presence of bromine, the formation of...

ea0063oc4.4 | Thyroid 1 | ECE2019

Cardiac and vascular characteristics of thyroid hormone resistance syndrome in France

Sibilia Paul , Briet Claire , Prunier-Mirebeau Delphine , Moal Valerie , Bouhours-Nouet Natacha , Coutant Regis , Rodien Patrice , Illouz Frederic

Introduction: The syndrome of reduced sensitivity to thyroid hormone (SRSTH) due to mutations of thyroid hormone receptor β (TRB) consists of an inappropriate secretion of TSH with elevated levels of thyroid hormones. Cardiovascular manifestations are often the ones that affect patients. Our aim was to evaluate the cardiac and vascular characteristics of patients with SRSTH due to TRB mutations.Materials and methods: We analysed cl...